Job Description

We are looking for a Senior Principal Scientist in Discovery Toxicology (DT) within the Pharmaceutical Candidate Optimization (PCO) organization at Bristol Myers Squibb. The role focuses on identifying and addressing toxicology issues across discovery programs that inform program advancement, lead candidate optimization, and progression into development.

Responsibilities

• Design, execute, interpret, and report toxicology studies for evaluating potential toxicity of new drug targets, including new approach methodologies, within drug discovery and communicate these results across multiple disciplines and governance bodies.
• Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or use of statistical programming to analyze large biological datasets (e.g., transcriptomics, proteomics) to investigate mechanisms of toxicity.
• Apply appropriate models and testing strategies to elucidate mechanisms of toxicity, assess human relevance, and design tools for proactive evaluation and prediction of liabilities associated with new drug entities.
• Participate in drug discovery teams as a toxicology expert, including communication of issues, experimental strategies for resolution, and interpretation of results.
• Discuss and enable transition of drug candidates into the BMS Development organization.
• Contribute to the collective research expertise in DT, including laboratory efforts to advance new tools and innovation in mechanistic toxicology research.

Required Qualifications

• PhD with 6+ years of academic/industry research experience in toxicology or a closely related field.
• Experience with computational toxicology approaches (e.g., in silico modeling, predictive toxicology, cheminformatics) and/or largescale data analysis, including machine learning, and ability to translate findings into actionable insights on safety for drug discovery programs.
• Versed in computational methods, with the ability to identify and evaluate emerging computational trends and make informed recommendations on their adoption to support early toxicology risk assessment strategies.
• Ability to generate thorough toxicology target liability assessments for proposed drug discovery targets, including providing suggested approaches and whether proactive followup is warranted based on weight of evidence.
• Strong communication skills, both verbal and written, are essential. The successful candidate is expected to work in a highly collaborative manner with an enterprise mindset and patientfocused values.

Preferred Qualifications

• PhD in toxicology or a closely related field with 6+ years of postdoctoral and pharmaceutical industry experience in drug discovery.
• Broad knowledge of toxicology, emphasizing investigation of molecular mechanisms of toxicity.
• Experience collaborating with computational teams and interfacing with IT to develop innovative approaches, enhancing toxicology prediction capabilities within the organization.
• Practical experience with organoids, microphysiological systems, or other newapproach methodologies.
• Experience in systems pharmacology or metabolismmediated toxicity.
• Strong skill set in design and implementation of mechanistic toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic or translational toxicology studies; ability to design in vivo studies across species is also desired.

Compensation Overview

Cambridge, MA (Crossing): $182,160 $220,729

Princeton, NJ: $158,390 $191,930

San Diego, CA: $174,230 $211,129

Additional incentive cash and stock opportunities may be available based on eligibility. Final compensation is determined by experience and skill set.

Benefits

• Medical, pharmacy, dental, and vision coverage.
• Wellbeing support, including the BMS Living Life Better program and employee assistance programs.
• 401(K) and other financialwellness resources.
• Paid national holidays, optional holidays, and flexible vacation options.
• Parental, caregiver, bereavement, and military leave.
• Other perks such as tuition reimbursement and recognition programs.

All qualified applicants are encouraged to apply. Bristol Myers Squibb is an equal opportunity employer. For complete EEO statement, visit careers.bms.com/eeo-accessibility.

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